We have measured the change of lung mechanical parameters on isolated rabbit lungs exposed to chlorine gas (Cl{in2}). Experimental results show parallel increase in elastance and resistance of impaired lungs. We tried to determine whether this may be explained by a reduction of the ventilated areas in the lung, consecutive to closure of some airways. We have then tried to simulate these experimental results by studying the effects of various airways occlusions imposed on two concurrent models (symmetrical and dissymmetrical) of (...) the tracheo-bronchial tree. For each model, we successively evaluated the resistance of the normal lung, simulated a partial peripheral airways occlusion and estimated the induced changes in total resistance. Analytical expressions of the "occluded lung" elastance and resistance have been found for the symmetrical model but not for the dissymmetrical model (a graphical approach is proposed). With the symmetrical model, simulated results are comparable to experimental ones when the occlusion level is proximal. Whatever the dissymmetry level (δ) of the fractal tree model, we could not simulate the expected increase in resistance with the observed increase in elastance. We conclude that either the occlusion is non homogeneous or the lung impairment is not only a reduction in ventilated areas. (shrink)

Ce livre retrace le parcours d'enseignant et de résistant de Georges Canguilhem, ainsi que ceux de Jean Cavaillès et de Jean-Paul Sartre, entre la fin des années 1920 et 1945. Il reconstitue également la genèse de la philosophie médicale de Canguilhem sur fond de politique médicale nazie d'extermination des "anormaux.

In lieu of an abstract, here is a brief excerpt of the content:Haiti Can't BreatheNéhémy Pierre-Dahomey (bio)Translated by David F. BellI'm not particularly familiar with recent politics in Haiti. Nor, as it were, with the contemporary history of the country. In some sense, the difference between recent politics and contemporary history is rather delicate. History would be the most profound social, political, and economic points of contention behind the daily lives of a population under siege. Not simply those talked (...) about while people travel in public transportation (Haitians talk a lot while in public transportation), but also the interpretive matrices mobilized to speak about these problems. As for current events, they are the province of newspaper headlines, those front pages and editorial pages most often read and shared, the public opinion machine.Of course, a few snippets of news come to me: the rise of kidnapping, political instability, the opposition declaring that the presidential mandate has ended, a government sponsored referendum to change the constitution, upcoming elections. As I write this piece (summer 2021), armed banditry is rife in many working-class neighborhoods. There are victims by the dozens nearly every day.As I was asking myself how best to express the bicentennial dyspnea of the Haitian people, I learned about the assassination of the president of the Republic in his private residence.Haiti could not breathe. Now it is suffocating.I recently published a novel entitled Combats (March 2021) in which the characters live in a nineteenth-century rural setting. They experience the full force of the first consequences provoked by the infamous independence debt, well understood by Haitians and analyzed by international specialists such as David Graeber and Thomas Piketty.After its independence in 1804, Haiti was not accepted into the concert of nations. The country, founded by hordes of previously enslaved Blacks and by freed Mulattos, was a bad example, a model not to be emulated so geographically near a slave society, the United States, and the Antilles belonging to France. No economic power, that is, no white country defining itself as such, recognized the independence of the new Black, abolitionist, and egalitarian population. The isolation of Haiti thus began at the very moment of its foundation. [End Page 165]In a vain attempt to escape the embargo and to construct a collective destiny at the international level, Haiti accepted a colossal debt imposed on it by France. Charles X, king of France and Navarre, forced Jean-Pierre Boyer, supreme leader of the Haitian nation, to assume the responsibility for a ransom of 120 million francs. The economist Thomas Piketty calculates that this was equivalent to 28 billion euros in today's currency. David Graeber, in his Debt: The First 500 Years, considers it to be the most egregious debt in history. In truth, for Haitians, this strange transaction consisted in buying lands they had already conquered in their independence struggle, having taken them from the previous colonial settlers representing the French state.Since the previously emancipated ancestors were considered the colonial settlers' property, Haitians, under threat from the French army, assumed the weight of this debt, which really consisted in purchasing—from their previous torturers—their very persons and those of their grandparents. In other words, after the war of independence, begun by Black Maroons as soon as they arrived on the island of Haiti, pursued by Toussaint Louverture against slavery, brought successfully to a conclusion by Jean Jacques Dessalines through victorious military battles (November 1803 at Vertières, for example), after this long road toward emancipation, France, supported by all the foreign powers of the period, extracted from Haiti recognition of the debt in 1826, that is, during the first half of the nineteenth century, at the very moment when the independent countries of the world were beginning to undergo a massive industrialization.Haiti clearly missed out on this entrance into the industrial age of the steam engine. It remained an "essentially agricultural" country because every year it had to pay debt service—including interest—every year until the second half of the 20th century!Like many others I saw the images of the white man, Derek Chauvin, resting his knee on George Floyd's neck for eight... (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Periodically, we take stock of SubStance and provide a brief statement regarding initiatives and priorities in the journal's interests. Three years ago, we announced that "Exploring hybrid writing with theoretical impact is at the center of our current preoccupations."1 Since that time, the journal has made significant changes. This issue marks our fourth issue of publishing with Johns Hopkins University Press in a transition that recognizes our new publisher as a leader among university presses.Our plan also expressed our intent to (...) move toward publishing digital work that exemplifies theoretical thinking in nonlinear, experimental forms. In 2018, we launched Digital SubStance, a platform for "hybrid work that... (shrink)

This issue of SubStance is the first since 2010 not dedicated to a specific theme or author; it features ten eclectic essays submitted from different disciplines and countries by well-established as well as emerging scholars. We wish to take this opportunity to emphasize the importance of these varia, which illustrate the range of our speculative and critical interests, and to signal directions we anticipate the journal moving in the near future. Beyond its interest in French literature and theory, SubStance has (...) always promoted a dialogue between contemporary theory and a multifaceted outside, an outside where contemporary theory may be used to investigate literary, philosophical, and artistic traditions.. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

This paper argues that English quantifier phrases of the form ‘every F’ admit of a literal referential interpretation, contrary to the standard semantic account of this expression, according to which it denotes a set and a second-order relation. Various arguments are offered in favor of the referential interpretation, and two likely objections to it are forestalled.

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

We show a transfer principle for the property that all types realised in a given elementary extension are definable. It can be written as follows: a Henselian valued field is stably embedded in an elementary extension if and only if its value group is stably embedded in its corresponding extension, its residue field is stably embedded in its corresponding extension, and the extension of valued fields satisfies a certain algebraic condition. We show for instance that all types over the Hahn (...) field $$\mathbb {R}((\mathbb {Z}))$$ are definable. Similarly, all types over the quotient field of the Witt ring $$W(\mathbb {F}_p^{\text {alg}})$$ are definable. This extends a work of Cubides and Delon and of Cubides and Ye. (shrink)

In this thesis, we study transfer principles in the context of certain Henselian valued fields, namely Henselian valued fields of equicharacteristic $0$, algebraically closed valued fields, algebraically maximal Kaplansky valued fields, and unramified mixed characteristic Henselian valued fields with perfect residue field. First, we compute the burden of such a valued field in terms of the burden of its value group and its residue field. The burden is a cardinal related to the model theoretic complexity and a notion of dimension (...) associated to $\text {NTP}_2$ theories. We show, for instance, that the Hahn field $\mathbb {F}_p^{\text {alg}})$ is inp-minimal, and that the ring of Witt vectors $W$ over $\mathbb {F}_p^{\text {alg}}$ is not strong. This result extends previous work by Chernikov and Simon and realizes an important step toward the classification of Henselian valued fields of finite burden. Second, we show a transfer principle for the property that all types realized in a given elementary extension are definable. It can be written as follows: a valued field as above is stably embedded in an elementary extension if and only if its value group is stably embedded in the corresponding extension of value groups, its residue field is stably embedded in the corresponding extension of residue fields, and the extension of valued fields satisfies a certain algebraic condition. We show, for instance, that all types over the power series field $\mathbb {R})$ are definable. Similarly, all types over the quotient field of $W$ are definable. This extends previous work of Cubides and Delon and of Cubides and Ye.These distinct results use a common approach, which has been developed recently. It consists of establishing first a reduction to an intermediate structure called the leading term structure, or $\operatorname {\mathrm {RV}}$ -sort, and then of reducing to the value group and residue field. This leads us to develop similar reduction principles in the context of pure short exact sequences of abelian groups.prepared by Pierre Touchard.E-mail: pierre[email protected]: https://miami.uni-muenster.de/Record/a612cf73-0a2f-42c4-b1e4-7d28934138a9. (shrink)

There are presently three broad approaches the project of naturalizing intentionality: a purely informational approach (Dretske and Fodor), a purely teleological approach (Millikan and Papineau), and a mixed informationally-based teleological approach (Dretske again). I will argue that the last teleosemantic theory offers the most promising approach. I also think, however, that the most explicit version of a pure teleosemantic theory of content, namely Millikan’s admirable theory, faces a pair of objections. My goal in this paper is to spell out Millikan’s (...) pure teleosemantic theory; then to present two objections; and finally to ask the question whether a teleosemantic framework can be saved from the objections. (shrink)

Published here is a critical edition of Augustine’s Sermons 293 and 299, the first edition since the Maurists. Sermon 293 was preached in Carthage on the 24th of June 413, feast of John the Baptist, at a time when infant baptism was a controversial question. Sermon 299 was delivered on the 29th of June, in honour of Peter and Paul : its manuscript transmission and thematic likeness with Sermon 293 suggest that it was preached, according to Pierre-Marie Hombert’s hypothesis, (...) in the same year in the same city, not five years later. Both texts, numbered among the longest of the De sanctis sermons, contradict Pelagian theses about the origin of death and the notion of human impeccability. (shrink)

De 1805 a 1830, Hegel professe neuf series de cours sur l'histoire de la philosophie. Explorant et meditant les pensees de ses predecesseurs, il en nourrit sa pensee et les eclaire en retour de la sienne. A ce titre, K.L. Michelet, a qui l'on doit la restitution de ces lecons a partir des notes de Hegel et de celles de ses auditeurs, voit dans ce texte la meileure cle pour la comprehension de son oeuvre. C'est par le berceau de la (...) philosophie, la Grece, que Hegel commence son exploration de l'histoire de la philosophie. Divisant la pensee grecque en trois periodes (la premiere s'etend de Thales a Aristote; la seconde englobe epicurisme, stoicisme et scepticisme; la troisieme, Platon et Aristote), il s'agit pour lui de partir du commencement de la pensee philosophante pour aboutir au stade ou l'idee prend la forme de la totalite. Ce deuxieme tome presente, au sein de la premiere periode, les lecons dediees aux sophistes (Protagoras, Gorgias), a Socrate et aux trois grandes ecoles socratiques: megarique (Euclide, Eubulide, Stilpon), cyrenaique (Aristippe, Theodore, Hegesias, Anniceris), cynique (Antisthene, Diogene et cyniques posterieurs). (shrink)

Religion privée, Opinion publique, ouvrage consacré à l’examen de la formation du syntagme « opinion publique », maître mot ou concept?, exige beaucoup de son lecteur. Cela tient d’une part au caractère particulièrement resserré du propos : en un espace relativement restreint se trouve concentrée une grande quantité de références empruntées à des horizons très divers, convoquées en vue d’éclairer la notion d’opinion publique, qui est ainsi replacée dans son devenir effectif, et non traitée f...